The effect of allelic variation in aldo-keto reductase 1C2 on the in vitro metabolism of dihydrotestosterone.

@article{Takahashi2009TheEO,
  title={The effect of allelic variation in aldo-keto reductase 1C2 on the in vitro metabolism of dihydrotestosterone.},
  author={Ryan H. Takahashi and Thomas A. Grigliatti and Ronald E. Reid and Kenneth Wayne Riggs},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={329 3},
  pages={1032-9}
}
Aldo-keto reductase (AKR) 1C2 is a human, cytosolic enzyme that has an important role in the deactivation of the potent androgen dihydrotestosterone (DHT). AKR1C2 can regulate the extent and duration of activation of the androgen receptor by catalyzing the reduction of DHT to the less potent receptor ligand 3alpha-diol. In this study, we functionally characterize in vitro the effect of 11 naturally occurring nonsynonymous single nucleotide polymorphisms on the ability of AKR1C2 to reduce DHT to… CONTINUE READING