The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease.

@article{Harwood2010TheEO,
  title={The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease.},
  author={Dylan G Harwood and Ari D. Kalechstein and Warren Barker and Silvia Strauman and Peter St George-Hyslop and Casandra Iglesias and David A. Loewenstein and Ranjan Duara},
  journal={International journal of geriatric psychiatry},
  year={2010},
  volume={25 5},
  pages={511-8}
}
OBJECTIVE This study examined the association between a history of heavy alcohol use and smoking, presence of the apolipoprotein-E epsilon 4 allele (APOE epsilon4), and age of disease onset in a community dwelling sample of 685 Alzheimer's disease (AD) patients spanning three ethnic groups. DESIGN Cross-sectional study of AD patients evaluated at a University-affiliated outpatient memory disorders clinic. SUBJECTS A clinic-based cohort of white non-Hispanic (WNH; n = 397), white Hispanic… CONTINUE READING

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