The effect of agonists and antagonists of platelet aggregation on von Willebrand factor-mediated platelet agglutination.

@article{Mcpherson1991TheEO,
  title={The effect of agonists and antagonists of platelet aggregation on von Willebrand factor-mediated platelet agglutination.},
  author={J. K. Mcpherson and Marjorie B. Zucker and Evelyn A Mauss and Sandra Brownlea},
  journal={Thrombosis and haemostasis},
  year={1991},
  volume={65 5},
  pages={573-7}
}
Ristocetin-induced platelet agglutination (RIPA) in EDTA-treated citrated platelet-rich plasma was reduced to 49 +/- 11% by 1.25 microM ADP, 41 +/- 14% by 1 microM A23187, and 26 +/- 7% by 0.1 microgram/ml platelet activating factor (PAF). The effect of 5-110 microM epinephrine was not dose-dependent, but varied between donors, with RIPA from 56-100% of the control. The inhibitory effects of these agonists were not altered by prior treatment of platelets with aspirin. Prior addition of 200… CONTINUE READING