The effect of aging on the subcellular distribution of estrogen receptor-alpha in the cholinergic neurons of transgenic and wild-type mice.

@article{Kalesnykas2005TheEO,
  title={The effect of aging on the subcellular distribution of estrogen receptor-alpha in the cholinergic neurons of transgenic and wild-type mice.},
  author={Giedrius Kalesnykas and Ulla Roschier and Jukka T. Puoliv{\"a}li and Jun Wang and Riitta Miettinen},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 5},
  pages={1437-42}
}
The degeneration of the basal forebrain cholinergic system plays an important role in cognitive deterioration in aging and Alzheimer's disease. Brain cholinergic neurons and their projections are affected by changes in the circulating levels of estrogens, which exert their effects mainly through the estrogen receptors. In this study, we investigated the effect of aging, estrogen status and transgenic genotype on the number of cholinergic neurons and the estrogen receptor alpha (ERalpha) content… CONTINUE READING

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