The effect of aging on the seminiferous epithelium of the brown Norway rat.

@article{Wright1993TheEO,
  title={The effect of aging on the seminiferous epithelium of the brown Norway rat.},
  author={William W. Wright and Chris Fiore and Barry R. Zirkin},
  journal={Journal of andrology},
  year={1993},
  volume={14 2},
  pages={110-7}
}
Aging of the mammalian testis is often accompanied by loss of germ cells and, as a result, decreased daily sperm production. It is currently unknown whether cell loss is the result of aging-related changes in germ cells or whether there are also aging-related changes in the Sertoli cells that normally support germ development and differentiation. To begin to compare the effects of age on germ cells and on Sertoli cells, we examined brown Norway rats of 6, 12, 18, 21, and 24 months of age for… CONTINUE READING