The effect of aging on cell-cycle kinetics and X-ray-induced chromosome aberrations in cultured lymphocytes from patients with Down syndrome.

@article{Takeshita1992TheEO,
  title={The effect of aging on cell-cycle kinetics and X-ray-induced chromosome aberrations in cultured lymphocytes from patients with Down syndrome.},
  author={Tatsuya Takeshita and C Ariizumi-Shibusawa and Ken Shimizu and Hidehisa Hoshino and Zentaro Yamagata and Sumio Iijima and Akio Asaka and Makoto Higurashi},
  journal={Mutation research},
  year={1992},
  volume={275 1},
  pages={
          21-9
        }
}
To evaluate the effects of aging on cytogenetic characteristics of lymphocytes from Down syndrome (DS), cell-cycle kinetics after PHA stimulation and chromosome-type aberration frequencies after X-ray exposure were investigated in vitro in the lymphocytes derived from 4 (or 3 for X-ray treatment) age groups of DS patients and age-matched controls. The results clearly showed higher mitotic and proliferation index levels in younger groups compared to older groups at the various culture intervals… CONTINUE READING
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