The effect of aging on OX40 agonist-mediated cancer immunotherapy

@article{Ruby2009TheEO,
  title={The effect of aging on OX40 agonist-mediated cancer immunotherapy},
  author={Carl E. Ruby and Andrew D. Weinberg},
  journal={Cancer Immunology, Immunotherapy},
  year={2009},
  volume={58},
  pages={1941-1947}
}
Agents that enhance T cell co-stimulatory signaling have emerged as promising cancer immunotherapies. Our laboratory has been evaluating the TNF receptor co-stimulatory molecule, OX40, which has the capacity to augment critical aspects of T cell function and induce tumor regression in animal models. Effective stimulation of OX40 expressing T cells was… CONTINUE READING