The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption.

@article{Lambert2004TheEO,
  title={The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption.},
  author={Adrian J Lambert and Bing Wang and Josephine Yardley and Jonathan B Edwards and Brian J. Merry},
  journal={Experimental gerontology},
  year={2004},
  volume={39 3},
  pages={289-95}
}
It has been proposed that part of the anti-aging mechanism of caloric restriction (CR) involves changes in mitochondrial function. To investigate this hypothesis, mitochondria from various tissues of male Brown Norway rats (fully fed and CR) were isolated and respiration rates determined. In mitochondria from liver, heart, brain and kidney, there were no significant effects of CR on state 4 mitochondrial respiration rate. Further experiments using liver mitochondria under a variety of… CONTINUE READING