The effect of ageing and immobilization on structure and function of human skeletal muscle fibres.

@article{DAntona2003TheEO,
  title={The effect of ageing and immobilization on structure and function of human skeletal muscle fibres.},
  author={Giuseppe D'Antona and Maria Antonietta Pellegrino and Raffaella Adami and Riccardo Rossi and Carmine Naccari Carlizzi and Monica Canepari and Bengt Saltin and Roberto Bottinelli},
  journal={The Journal of physiology},
  year={2003},
  volume={552 Pt 2},
  pages={
          499-511
        }
}
Biopsy samples were taken from vastus lateralis muscle of seven young (YO, age 30.2 +/- 2.2 years), and seven elderly (EL, age 72.7 +/- 2.3 years) subjects and two elderly subjects whose right leg had been immobilized for 3.5 months (EL-IMM, ages 70 and 75). The following main parameters were studied: (1) myosin heavy chain (MHC) isoform distribution of the samples, determined by SDS-PAGE; (2) cross-sectional area (CSA), specific force (Po/CSA) and maximum shortening velocity (Vo) of a large… CONTINUE READING
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