The effect of age on the response of the rat brains to continuous beta-amyloid infusion.

@article{Nag2001TheEO,
  title={The effect of age on the response of the rat brains to continuous beta-amyloid infusion.},
  author={Sangram Nag and F. C. Archie Tang},
  journal={Brain research},
  year={2001},
  volume={889 1-2},
  pages={303-7}
}
Young (3 months old) and aging (18-21 months old) rats were infused intracerebroventricularly with beta-amyloid (1-40; 4.2 nmol) for 14 days. In both age groups, beta-amyloid led to deficits in water-maze and decreased choline acetyltransferase activity and somatostatin levels. Cortical substance P levels also decreased whereas neuropeptide Y levels remained unaltered. There were no significant age dependent differences among these neurochemicals except a decrease in hippocampal neuropeptide Y… CONTINUE READING