The effect of age on the pharmacokinetics of levodopa administered alone and in the presence of carbidopa.

@article{Robertson1989TheEO,
  title={The effect of age on the pharmacokinetics of levodopa administered alone and in the presence of carbidopa.},
  author={D. R. C. Robertson and Nolan D Wood and H Everest and Kenneth G. Monks and Derek G. Waller and Andrew G. Renwick and Charles F. P. George},
  journal={British journal of clinical pharmacology},
  year={1989},
  volume={28 1},
  pages={61-9}
}
1. The effect of age on the pharmacokinetics of levodopa administered alone and in the presence of carbidopa was investigated in young and elderly healthy volunteers. 2. The plasma clearance of levodopa following intravenous administration of 50 mg was 14.2 +/- 2.8 (s.d.) ml min-1 kg-1 in the elderly compared with 23.4 +/- 4.1 ml min-1 kg-1 in the young (P less than 0.01) which resulted in a 49% greater area under the plasma concentration-time curve (AUC) in the older subjects (P less than 0.01… CONTINUE READING

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