The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats.

@article{Comai2005TheEO,
  title={The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats.},
  author={Stefano Comai and Carlo Virgilio Luigi Costa and Eugenio Ragazzi and Antonella Bertazzo and Graziella Allegri},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2005},
  volume={360 1-2},
  pages={
          67-80
        }
}
  • S. Comai, C. Costa, G. Allegri
  • Published 1 October 2005
  • Biology, Medicine
  • Clinica chimica acta; international journal of clinical chemistry
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats
TLDR
Age‐associated changes in tryptophan metabolism have the potential to impact upon major biological processes, including lymphocyte function, pyridine (NAD(P)(H)) synthesis and N‐methyl‐d‐aspartate (NMDA)‐mediated synaptic transmission, and may therefore contribute to several degenerative changes of the elderly.
Effects of Various Kynurenine Metabolites on Respiratory Parameters of Rat Brain, Liver and Heart Mitochondria
TLDR
Alterations of L-tryptophan metabolism might have an impact on the bioenergetic activities of brain, liver and/or heart mitochondria and might be involved in the development of clinical symptoms such as cardiomyopathy, hepatopathy and dementia.
Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases
TLDR
Each kynurenine is described remarking their redox properties, their effects in experimental models, their alterations in the aging process, and their roles in bioenergetic and biosynthetic metabolism.
Kynurenine metabolism in health and disease
TLDR
Current knowledge about the mechanisms of kynurenine production and routes of its clearance is presented and the involvement of knurenine and its metabolites in the biology of different T cell subsets (including Th17 cells and regulatory T cells) and neuronal cells is discussed.
Role of Kynurenine Pathway in Aging
TLDR
The alteration in kynurenine pathway components during aging is reviewed and the relationship between these metabolites and other factors present during the aging process is studied, with the goal of exploring their therapeutic value, as targets or biomarkers of different age diseases or aging states.
Decline in Liver Mitochondria Metabolic Function Is Restored by Hochuekkito Through Sirtuin 1 in Aged Mice With Malnutrition
TLDR
The findings suggested that the decrease in locomotor activity in aged FR mice was associated with a decline in the metabolic function of hepatic mitochondria via decreased SIRT1 expression, which was restored by HET treatment, implying that enhancing the metabolicfunction of liver mitochondria can contribute to alleviating energy deficiency in the elderly.
Kynurenic Acid Acts as a Signaling Molecule Regulating Energy Expenditure and Is Closely Associated With Metabolic Diseases
TLDR
A perspective on the current knowledge regarding the biological effects of KYNA in metabolic diseases and perinatal nutrition is provided.
Modulation of the Paracrine Kynurenic System in Bone as a New Regulator of Osteoblastogenesis and Bone Mineral Status in an Animal Model of Chronic Kidney Disease Treated with LP533401
TLDR
The presence of a TDO-dependent, paracrine kynurenic system in the bone of rats with CKD was discovered and its modulation during LP533401 treatment was associated with impaired bone mineral status.
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References

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Relationship between tryptophan metabolism and vitamin B6 and nicotinamide in aged subjects.
TLDR
As the abnormal tryptophan metabolism in aging seemed to be in connection with vitamin B6 and nicotinamide, in a group of 7 aged sugjects the urinary excretory pattern is normalized after vitamin administration.
Modulation of Quinolinic and Kynurenic Acid Content in the Rat Brain: Effects of Endotoxins and Nicotinylalanine
TLDR
The possibility of significantly increasing brain concentrations of kynurenic acid without a concomitant increase in quinolinic acid may provide a useful approach for studying the role of these electrophysiologically active tryptophan metabolites in brain function and preventing the possible toxic actions of abnormal synthesis of quinoliniic acid.
The preferred route of kynurenine metabolism in the rat.
The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.
TLDR
It is suggested that the saturation of rat liver apo-(tryptophan pyrrolase) with its haem activator can be modified by treatment known to cause destruction, inhibition of synthesis, increased utilization and enhanced synthesis of liver haem.
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