The effect of age on plasma levels of propranolol and practolol in man.

  title={The effect of age on plasma levels of propranolol and practolol in man.},
  author={Christopher M Castleden and Col Michael A. Kaye and Rodney L Parsons},
  journal={British journal of clinical pharmacology},
  volume={2 4},
1. Plasma levels of propranolol and practolol were measured in groups of elderly and young subjects, after the oral administration of propranolol (40 mg) and practolol (200 mg) on separate occasions. 2. At all sampling times the mean plasma propranolol level in the group of elderly subjects was substantially greater than the corresponding level in the group of young subjects, there being a significant difference between the two, and a fourfold difference in the mean peak levels. 3. After… CONTINUE READING

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