The effect of additive compounds on glycerol-induced damage to human chondrocytes.

  title={The effect of additive compounds on glycerol-induced damage to human chondrocytes.},
  author={Joshua Hahn and L. Laouar and J. A. Elliott and G. Korbutt and N. Jomha},
  • Joshua Hahn, L. Laouar, +2 authors N. Jomha
  • Published 2017
  • Chemistry, Medicine
  • Cryobiology
  • High concentrations of cryoprotective agents are required for cryopreservation techniques such as vitrification. Glycerol is a common cryoprotective agent used in cryopreservation protocols but this agent is toxic at high concentrations. This work is an attempt to mitigate the toxic effects of high concentrations of glycerol on intact chondrocytes in human knee articular cartilage from total knee arthroplasty patients by simultaneous exposure to glycerol and a variety of additive compounds. The… CONTINUE READING
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