The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart.

@article{Downar1977TheEO,
  title={The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart.},
  author={Eugene Downar and Michiel J. Janse and Dirk Durrer},
  journal={Circulation},
  year={1977},
  volume={56 2},
  pages={
          217-24
        }
}
Subepicardial transmembrane potentials were recorded from intact pig hearts to observe the changes induced by acute ischemia. Ischemia shortened action potential duration, and decreased its amplitude, upstroke velocity, and resting potential. The cells were unresponsive after 12 to 15 minutes of coronary artery occlusion, yet near normal action potentials could be restored by flushing the occluded artery with saline as late as 40 minutes after occlusion. The unipolar extracellular electrogram… CONTINUE READING

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