The effect of acute branched-chain amino acid supplementation on prolonged exercise capacity in a warm environment

  title={The effect of acute branched-chain amino acid supplementation on prolonged exercise capacity in a warm environment},
  author={Phillip Watson and Susan M. Shirreffs and Ronald J. Maughan},
  journal={European Journal of Applied Physiology},
Eight males were recruited to examine the effect of branched-chain amino acid (BCAA) supplementation on exercise capacity in a glycogen-depleted state in a warm environment. Following a exercise and dietary regimen designed to reduce glycogen availability, subjects returned to the laboratory the following morning and remained seated for 2 h, before cycling to volitional exhaustion at 50% V̇O2 peak in a warm environment [30.0 (0.2)°C; mean (SD)]. Four 250 ml aliquots of a 12 g l−1 BCAA solution… 

Branched-chain amino acid supplementation increases the lactate threshold during an incremental exercise test in trained individuals.

The effects of branched-chain amino acid (BCAA) supplementation on the lactate threshold (LT) were investigated as an index of endurance exercise capacity and suggest that BCAA supplementation may be effective to increase the Endurance exercise capacity.

Effects of dietary leucine supplementation on exercise performance

Six weeks’ dietary leucine supplementation significantly improved endurance performance and upper body power in outrigger canoeists without significant change in the plasma ratio of tryptophan to BCAA.

Branched-chain amino acid supplementation does not affect endurance exercise capacity in man

The aim of the present investigation was to determine whether there are responders and non-responders to BCAA supplementation, and to define exhaustion as the point at which subjects could not maintain a pedal cadence of >50 rev/min despite verbal encouragement.

Acute tryptophan depletion does not improve endurance cycling capacity in a warm environment

Endurance cycling capacity in a warm environment is not improved by acute tryptophan depletion, suggesting tryPTophan availability is not a significant factor in the development of fatigue in such situations.

The influence of carbohydrate and protein ingestion during recovery from prolonged exercise on subsequent endurance performance

In conclusion, increasing the energy content of these recovery solutions extended run time to exhaustion, irrespective of whether the additional energy originated from sucrose or whey protein isolate.

A Combination of Amino Acids and Caffeine Enhances Sprint Running Capacity in a Hot, Hypoxic Environment.

Co-ingestion of caffeine and EAA appears to maintain muscle activation and central drive, with a small improvement in running performance.

Acute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditions

It appears that bupropion enabled subjects to maintain a greater TT power output in the heat with the same perception of effort and thermal stress reported during the placebo trial, despite the attainment of a higher core temperature.

Effects of Glutamine and Alanine Supplementation on Central Fatigue Markers in Rats Submitted to Resistance Training

It is found that glutamine and alanine may improve or impair central fatigue markers depending on their supplementation form, and Amino acids affected fatigue parameters depending on the supplementation form.

Interrelationship between physical activity and branched-chain amino acids.

No valid scientific evidence supports the commercial claims that orally ingested BCAAs have an anticatabolic effect during and after exercise in humans or that BCAA supplements may accelerate the repair of muscle damage after exercise.



Branched-chain amino acids prolong exercise during heat stress in men and women.

Results indicate BCAA supplementation prolongs moderate exercise performance in the heat and results indicate psychological data were not influenced by BCAA, and cardiovascular and thermoregulatory data were similar between treatments.

Pre-exercise branched-chain amino acid administration increases endurance performance in rats.

It is demonstrated that BCAA administration in rats results in enhanced endurance performance and an increase in blood ammonia during exercise.

Effect of branched-chain amino acid and carbohydrate supplementation on the exercise-induced change in plasma and muscle concentration of amino acids in human subjects.

A supply of CHO + BCAA or CHO alone did not affect the exercise-induced increase in the plasma and muscle concentration of aromatic amino acids, indicating that neither BCAA nor CHO influenced the net protein degradation during exercise.

Ingestion of branched‐chain amino acids and tryptophan during sustained exercise in man: failure to affect performance.

The data suggest that manipulation of tryptophan supply to the brain either has no additional effect upon serotoninergic activity during prolonged exhaustive exercise or that manipulations of serotoninergic activities functionally does not contribute to mechanisms of fatigue.

Effect of branched-chain amino acids (BCAA), glucose, and glucose plus BCAA on endurance performance in rats.

The hypothesis that the effect of BCAA administration on performance could be related to carbohydrate availability during exercise is supported.

Influence of ingesting a solution of branched-chain amino acids on perceived exertion during exercise.

The performance in the colour task of Stroops Colour Word Test performed after exercise was improved when BCAAs had been ingested during exercise, compared with the results from the placebo trial.

Effects of carbohydrate feedings on plasma free tryptophan and branched-chain amino acids during prolonged cycling

Free Trp and free Trp/BCAA increase progressively during prolonged cycling to fatigue, and changes in plasma free fatty acids probably play a prominent role in these responses.

Effect of initial muscle glycogen levels on protein catabolism during exercise.

  • P. LemonJ. Mullin
  • Medicine, Biology
    Journal of applied physiology: respiratory, environmental and exercise physiology
  • 1980
It was concluded that protein is utilized during exercise to a greater extent than is generally assumed and that under certain conditions protein carbon may contribute significantly to exercise caloric cost.

Effects of glucose, glucose plus branched-chain amino acids, or placebo on bike performance over 100 km.

It is suggested that neither glucose nor glucose plus glucose plus BCAA ingestion during 100 km of cycling enhance performance in well-trained cyclists.

Low glycogen and branched-chain amino acid ingestion do not impair anaplerosis during exercise in humans.

The data suggest that increasing the rate of BCAA oxidation has no measurable effect on muscle TCAI during exercise with low glycogen in humans, and it appears that low resting glycogen per se does not impair the increase in T CAI during moderate exercise.