The effect of activated protein C on experimental acute necrotizing pancreatitis

  title={The effect of activated protein C on experimental acute necrotizing pancreatitis},
  author={Levent Yamenel and Mehmet Refik Mas and Bilgin Comert and Ahmet Turan Isik and Sezai Aydin and N N{\"u}ket Mas and Salih Deveci and Mustafa Gorkem Ozyurt and Ilker Tasci and Tahir Unal},
  journal={Critical Care},
  pages={R184 - R190}
INTRODUCTION Acute pancreatitis is a local inflammatory process that leads to a systemic inflammatory response in the majority of cases. Bacterial contamination has been estimated to occur in 30-40% of patients with necrotizing pancreatitis. Development of pancreatic necrosis depends mainly on the degree of inflammation and on the microvascular circulation of the pancreatic tissue. Activated protein C (APC) is known to inhibit coagulation and inflammation, and to promote fibrinolysis in… CONTINUE READING


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