In the present study we investigated the potential antipsychotic effects of the mGlu2/3 agonist LY379268 on changes in EEG power spectra and coherence in the ketamine model of psychosis. In order to use behaviorally active drug doses, experiments detecting changes in locomotor activity and sensorimotor gating were also conducted. In EEG experiments, adult… (More)
Fig. 5.Duration of behavioral activity andmean absolute power spectra of behavioral activity compared to inactivity. (a) Duration of behavioral activity in animals during the EEG recording after administration of ketamine 30 mg/kg (KET), LY379268 3 mg/kg (LY), the vehicle (VEH) and co-administration of ketamine 30 mg/kg + LY379268 3 mg/kg (KET/LY). Ketamine 30 mg/kg increased the duration of behavioral activity. LY379268 3 mg/kg shortened the period of behavioral activity itself as well as in ketamine-treated animals. * and *** indicate p b 0.05 and 0.001 compared to the vehicle.+++ indicates p b 0.001 compared to ketamine 30 mg/kg. (b) The graphs show the effects of the treatmentswith ketamine 30 mg/kg (KET) and the vehicle (VEH) on the absolute power spectra compared to EEG epochs corresponding to behavioral activity versus inactivity. Data are expressed per 1 Hz as a percent change of activity from inactivity (zero line) with±SEM × 100 / mean absolute power of corresponding inactivity. Significant differences calculated for the mean power within the whole spectral bands are shown in the upper part of the figure (paired T-test). Behavioral activity increased the mean absolute power in the ketamine as well as vehicle treated animals. Significant increaseswere in the delta and theta bands for ketamine and in the theta, alpha, high beta and low-gamma bands in the vehicle treated animals. * and ** indicate p b 0.05–0.01 for ketamine 30 mg/kg. + and ++ indicate p b 0.05–0.01 for the vehicle treated animals.