The effect of acetazolamide on cerebral blood flow and oxygen utilization in the rhesus monkey.

@article{Laux1978TheEO,
  title={The effect of acetazolamide on cerebral blood flow and oxygen utilization in the rhesus monkey.},
  author={B E Laux and Marcus E. Raichle},
  journal={The Journal of clinical investigation},
  year={1978},
  volume={62 3},
  pages={585-92}
}
The brain is critically dependent for its moment to moment function and survival on an adequate supply of oxygen. The enzyme carbonic anhydrase (EC 4.2.1.1) may play an important role in oxygen delivery to brain tissue by facilitating the hydration of metabolically produced carbon dioxide in erythrocytes in brain capillaries, thus permitting the Bohr effect to occur. We examined the effect of 30 mg/kg i.v. acetazolamide, a potent inhibitor of carbonic anhydrase, upon cerebral blood flow and… CONTINUE READING
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The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time

  • Ter-Pogossian
  • Stroke
  • 1974

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