The effect of acetaminophen nanoparticles on liver toxicity in a rat model

  title={The effect of acetaminophen nanoparticles on liver toxicity in a rat model},
  author={Esmaeil Biazar and Seyed Mahdi Rezayat and Naser Montazeri and Khalil Pourshamsian and Reza Zeinali and Azadeh Asefnejad and Mehdi Rahimi and Mohammadmajid Zadehzare and Mehran Mahmoudi and Rohollah Mazinani and Mehdi Ziaei},
  booktitle={International journal of nanomedicine},
Acetaminophen, a pain-reliever, is one of the most widely used medications in the world. Acetaminophen with normal dosage is considered a nontoxic drug for therapeutic applications, but when taken at overdose levels it produces liver damage in human and various animal species. By a high energy mechanically activated method, we produced acetaminophen in a nanometer crystalline size (24 nm). Forty-eight hours after injection of crystalline particles with normal and reduced size of our drug, the… CONTINUE READING


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