The effect of a xanthine derivative, 1-(5' oxohexyl)-3-methyl-7-propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits.

@article{Hudlick1981TheEO,
  title={The effect of a xanthine derivative, 1-(5' oxohexyl)-3-methyl-7-propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits.},
  author={Olga Hudlick{\'a} and Julius Kom{\'a}rek and A. J. Wright},
  journal={British journal of pharmacology},
  year={1981},
  volume={72 4},
  pages={
          723-30
        }
}
1. The effect of a new xanthine derivate 1-5' oxohexyl-3-methyl-7-propylxanthine (HWA 285) was studied on heart performance in dogs and rabbits and on regional blood flow in rabbits. 2. Heart performance (cardiac output and dP/dt max) in dogs was increased. Cardiac work (calculated as CO x mean BP) was not changed in dogs and did not change or was slightly decreased in rabbits. Heart rate was increased in dogs and unchanged in rabbits. 3. Blood pressure decreased slightly in dogs, and more… CONTINUE READING