The effect of a single dose of osteoprotegerin in postmenopausal women.

@article{Bekker2001TheEO,
  title={The effect of a single dose of osteoprotegerin in postmenopausal women.},
  author={Pirow J. Bekker and Donna L Holloway and Arline Nakanishi and M Arrighi and Philip T. Leese and Colin Robert Dunstan},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2001},
  volume={16 2},
  pages={348-60}
}
Osteoprotegerin (OPG), a tumor necrosis factor (TNF) receptor family member, is a critical regulator of bone resorption. It is an important inhibitor of the terminal differentiation and activation of osteoclasts. This randomized, double-blind, placebo-controlled, sequential dose escalation study was conducted in postmenopausal women to determine the effect of a single subcutaneous (s.c.) dose of OPG on bone resorption as indicated by the biochemical markers, urinary N-telopeptide (NTX) and… CONTINUE READING