The effect of a novel tobacco process on the in vitro cytotoxicity and genotoxicity of cigarette smoke particulate matter.

@article{Combes2012TheEO,
  title={The effect of a novel tobacco process on the in vitro cytotoxicity and genotoxicity of cigarette smoke particulate matter.},
  author={Robert David Combes and Ken C. Scott and Deborah Dillon and Clive Meredith and Kevin Gerard McAdam and Chris Proctor},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2012},
  volume={26 6},
  pages={1022-9}
}
Some of the toxic effects of smoking have been attributed to the combustion of nitrogenous protein in tobacco. The effects of a treatment which reduces tobacco's protein nitrogen level, on the in vitro cytotoxicity and genotoxicity of cigarette smoke particulate matter (PM), were measured. PMs were tested in the Neutral Red Uptake (NRU) test; the Salmonella mutagenicity assay (SAL); the mouse lymphoma mammalian cell mutation assay (MLA) and the in vitro micronucleus test (IVMNT). PMs from all… CONTINUE READING

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