The effect of a new gastric proton pump inhibitor on serotonin-induced gastric mucosal lesions in rats

@article{Tsukamoto1988TheEO,
  title={The effect of a new gastric proton pump inhibitor on serotonin-induced gastric mucosal lesions in rats},
  author={Yoshihisa Tsukamoto and Saburo Nakazawa and Kose Segawa and Hidemi Goto and Akira Fukui and Kenichi Takano and Satoshi Hase and Tomiyasu Arisawa and Toshimasa Osada and Yoshinori Kawabe},
  journal={Gastroenterologia Japonica},
  year={1988},
  volume={23},
  pages={501-505}
}
The anti-ulcer effect of NC-1300, a new proton pump inhibitor, and its effect on gastric mucosal blood flow were studied in rats. Acute gastric mucosal lesions were induced by the subcutaneous administration of serotonin, 20 mg/kg. Using the electrolytically generated hydrogen gas clearance technique, it was determined that such gastric ulceration resulted… CONTINUE READING