The effect of a high-protein, high-sodium diet on calcium and bone metabolism in postmenopausal women and its interaction with vitamin D receptor genotype

@article{Harrington2004TheEO,
  title={The effect of a high-protein, high-sodium diet on calcium and bone metabolism in postmenopausal women and its interaction with vitamin D receptor genotype},
  author={Mary Harrington and T Bennett and Jette Jakobsen and Lars Ovesen and Christine Brot and Albert Flynn and Kevin D. Cashman},
  journal={British Journal of Nutrition},
  year={2004},
  volume={91},
  pages={41 - 51}
}
The influence of a high-Na, high-protein (calciuric) diet on Ca and bone metabolism was investigated in postmenopausal women (aged 50–67 years) who were stratified by vitamin D receptor (VDR) genotype. In a crossover trial, twenty-four women were randomly assigned to a diet high in protein (90 g/d) and Na (180 mmol/d) or a diet adequate in protein (70 g/d) and low in Na (65 mmol/d) for 4 weeks, followed by crossover to the alternative dietary regimen for a further 4 weeks. Dietary Ca intake was… 
View on Cambridge Press
cambridge.org
40 Citations
Highly Influential Citations
3
Background Citations
17
Methods Citations
1
Results Citations
2

40 Citations

Citation Type

Citation Type

Effect of a high-protein, high-salt diet on calcium and bone metabolism in postmenopausal women stratified by hormone replacement therapy use
TLDR
It appears that postmenopausal HRT use attenuates the increase in a marker of bone resorption associated with a calciuric diet.
Effects of a low sodium diet on bone metabolism
TLDR
Findings suggest that in postmenopausal women with sodium intakes ≥3.4 g/day, a low sodium diet may have benefits for skeletal health.
Sodium and Bone Health: Impact of Moderately High and Low Salt Intakes on Calcium Metabolism in Postmenopausal Women
TLDR
Salt was responsible for a significant change in bone calcium balance, from positive to negative, when consumed as part of a high calcium diet, but with a low calcium intake, theBone calcium balance was negative on both high and low salt diets.
Effect of dietary salt intake on circadian calcium metabolism, bone turnover, and calcium oxalate kidney stone risk in postmenopausal women
The Effect of a six month low-carbohydrate diet on the biomarkers of bone health in pre- and post-menopausal women: a randomised control crossover trial
TLDR
Increased bone resorption observed in this study without concomitant increased bone formation suggests this diet could cause poor bone health over time.
The influence of habitual salt intake on bone remodelling in young healthy people
TLDR
The present results could not confirm that habitual sodium intake above recommended levels affects bone remodelling processes or decreases bone mineral density in young healthy people if combined with adequate calcium intake.
The effect of protein diets in postmenopausal women with osteoporosis: Systematic review of randomized controlled trials
TLDR
It is shown that both combined administration of proteins through diet and supplements and single administration through protein supplements may reduce the risk of fracture in postmenopausal osteoporotic women.
Effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men
TLDR
Under the conditions tested in this double-blind, placebo-controlled trial in adult men, a CLA supplement of mixed isomers did not affect markers of calcium or bone metabolism.
The relationship between sodium intake and some bone minerals and osteoporosis risk assessment instrument in postmenopausal women
TLDR
Although urinary calcium and potassium increased with the increase in sodium intake, no relationship was found between sodium and ORAI.
The Association of Dietary and Urinary Sodium With Bone Mineral Density and Risk of Osteoporosis: A Systematic Review and Meta-Analysis
TLDR
A positive association between sodium intake and the risk of OS was found, while no association was found with urinary sodium and there was no significant correlation between Sodium intake and BMD.
...
1
2
3
4
...

References

SHOWING 1-10 OF 84 REFERENCES
Short-term effects of dietary sodium intake on bone metabolism in postmenopausal women measured using urinary deoxypyridinoline excretion
TLDR
It is concluded that varying dietary Na intake may affect Ca and Mg metabolism, but it was unable to demonstrate an effect on bone resorption at the levels of intake used.
EFFECTS OF A HIGH PROTEIN INTAKE FROM COMMON FOODS ON CALCIUM METABOLISM IN A COHORT OF POSTMENOPAUSAL WOMEN
The effect of dietary sodium intake on biochemical markers of bone metabolism in young women
TLDR
The Na-induced calciuria observed in the Na-sensitive healthy young women did not result in increased bone resorption or turnover and, despite restricted Ca intake, adaptation of dietary Ca absorption may have compensated for the increased urinary Ca loss.
Short-term changes in calcium but not protein intake alter the rate of bone resorption in healthy subjects as assessed by urinary pyridinium cross-link excretion.
TLDR
Data indicate that a short-term increase in calcium intake is accompanied by a reduced rate of bone resorption and that this effect is independent of dietary protein intake.
Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes.
TLDR
Intakes of caffeine in amounts >300 mg/d ( approximately 514 g, or 18 oz, brewed coffee) accelerate bone loss at the spine in elderly postmenopausal women.
Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women.
TLDR
Increasing protein intake may have a favorable effect on change in BMD in elderly subjects supplemented with calcium citrate malate and vitamin D.
The effect of dietary sodium on calcium metabolism in premenopausal and postmenopausal women
TLDR
It appears that post menopausal, but not premenopausal, women respond to a high sodium diet by an increase in bone resorption which may lead to reduced bone density.
Changes in bone turnover in young women consuming different levels of dietary protein.
TLDR
The data suggest that at high levels of dietary protein, at least a portion of the increase in urinary calcium reflects increased bone resorption, as well as a compensatory increase in bone formation.
Effect of level of protein intake on calcium metabolism and on parathyroid and renal function in the adult human male.
TLDR
Urinary calcium was elevated significantly when the protein intake was increased and the increase in urinary calcium caused by the high protein diet appears to be due in part to an increase in the filtered load of calcium by the glomeruli and a decrease in calcium reabsorption by the renal tubules.
The role of dietary sodium on renal excretion and intestinal absorption of calcium and on vitamin D metabolism.
TLDR
It is concluded that in normal subjects, Na-induced renal hypercalciuria is accompanied by increased 1,25-(OH)2D synthesis and enhanced intestinal Ca absorption and mediation by PTH is suggested.
...
1
2
3
4
5
...