The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer.

@article{Sharpe2013TheEO,
  title={The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer.},
  author={Kevin Sharpe and Grant S Stewart and Alan Mackay and Christophe Van Neste and Charlotte Rofe and Daniel Berney and Irfan A. Kayani and Axel Bex and Elaine Wan and Fiach C. O'Mahony and Marie O'Donnell and Simon Chowdhury and Rukma Doshi and Colan Ho-Yen and Marco Gerlinger and Dawn J Baker and Neil Smith and Barry R. Davies and Anju Sahdev and Ekaterini Boleti and Tim De Meyer and Wim Van Criekinge and Luis Beltr{\'a}n and Yong-Jie Lu and David J. Harrison and Andrew R. Reynolds and Thomas B Powles},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 24},
  pages={6924-34}
}
PURPOSE To investigate how biologically relevant markers change in response to antiangiogenic therapy in metastatic clear cell renal cancer (mRCC) and correlate these changes with outcome. EXPERIMENTAL DESIGN The study used sequential tumor tissue and functional imaging (taken at baseline and 12-16 weeks) obtained from three similar phase II studies. All three studies investigated the role of VEGF tyrosine kinase inhibitors (TKI) before planned nephrectomy in untreated mRCC (n = 85). The… CONTINUE READING
31 Citations
38 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Similar Papers

Loading similar papers…