The effect of UV-B irradiation on primary and secondary HSV-1 infections in interleukin-4 knockout mice

@article{ElGhorr1999TheEO,
  title={The effect of UV-B irradiation on primary and secondary HSV-1 infections in interleukin-4 knockout mice},
  author={Ali A El-Ghorr and Mary Norval},
  journal={Archives of Dermatological Research},
  year={1999},
  volume={291},
  pages={459-465}
}
Ultraviolet B (UV-B) irradiation suppresses cell-mediated immunity and may lead to increased susceptibility to infectious diseases. Limited evidence suggests that exposure promotes a T helper (Th) 2 type of cytokine response with abrogation of a Th1 response. Several putative mediators of UV-induced immunosuppression have been identified, of which interleukin-4 (IL-4), an example of a Th2 cytokine, is one. Primary and secondary epidermal infections with herpes simplex virus (HSV) type 1 in IL-4… CONTINUE READING

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