The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.

Abstract

Pilocarpine-induced status epilepticus (SE), which results in temporal lobe epilepsy (TLE) in rodents, activates the JAK/STAT pathway. In the current study, we evaluate whether brief exposure to a selective inhibitor of the JAK/STAT pathway (WP1066) early after the onset of SE affects the severity of SE or reduces later spontaneous seizure frequency via… (More)
DOI: 10.1016/j.nbd.2013.09.003

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@article{Grabenstatter2014TheEO, title={The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.}, author={Heidi Grabenstatter and Yasmin Cruz Del Angel and Jessica Carlsen and Michael F. Wempe and Andrew M. White and Meaghan Cogswell and Shelley J. Russek and Amy R Brooks-Kayal}, journal={Neurobiology of disease}, year={2014}, volume={62}, pages={73-85} }