The effect of SQ14,225 on systolic blood pressure and urinary excretion of vasopressin in the developing spontaneously hypertensive rat.

In order to assess the relationship in the spontaneously hypertensive (SH) rat between the development of hypertension and the increased secretion of vasopressin which we have shown in this model, SH rats were treated with the orally effective converting enzyme inhibitor, SQ 14,225 (15 to 30 mg/kg-day in the drinking water), from ages 33 to 61 days… (More)