The effect of SK&F 95654, a novel phosphodiesterase inhibitor, on cardiovascular, respiratory and platelet function.

@article{Murray1992TheEO,
  title={The effect of SK&F 95654, a novel phosphodiesterase inhibitor, on cardiovascular, respiratory and platelet function.},
  author={Keith J. Murray and R. J. Eden and J S Dolan and David C. Grimsditch and Cathy Stutchbury and Bela P Patel and Anne Knowles and Angela Worby and James A. Lynham and W J Coates},
  journal={British journal of pharmacology},
  year={1992},
  volume={107 2},
  pages={463-70}
}
1. SK&F 95654 inhibited the guanosine 3':5'-cyclic monophosphate (cyclic GMP)-inhibited phosphodiesterase (cGI-PDE) with an IC50 value of 0.7 microM. The IC50 values were greater than 100 microM for the other four phosphodiesterase isoenzymes tested. The R-enantiomer of SK&F 95654 (IC50 = 0.35 microM) was a more potent inhibitor of cGI-PDE than was the S-enantiomer (IC50 = 5.3 microM). 2. In the guinea-pig working heart, SK&F 95654 produced a positive inotropic response without altering heart… CONTINUE READING