The effect of RAAS blockade on the progression of diabetic nephropathy

@article{Roscioni2014TheEO,
  title={The effect of RAAS blockade on the progression of diabetic nephropathy},
  author={Sara S. Roscioni and Hiddo J. Lambers Heerspink and Dick de Zeeuw},
  journal={Nature Reviews Nephrology},
  year={2014},
  volume={10},
  pages={77-87}
}
The renin–angiotensin–aldosterone system (RAAS) has a key role in the regulation of blood pressure, sodium and water balance, and cardiovascular and renal homeostasis. In diabetic nephropathy, excessive activation of the RAAS results in progressive renal damage. RAAS blockade using angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers is the cornerstone of treatment of diabetic renal disease. Alternative RAAS-blockade strategies include renin inhibition and aldosterone… CONTINUE READING

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