The effect of RAAS blockade on markers of renal tubular damage in diabetic nephropathy: u-NGAL, u-KIM1 and u-LFABP.

@article{Nielsen2012TheEO,
  title={The effect of RAAS blockade on markers of renal tubular damage in diabetic nephropathy: u-NGAL, u-KIM1 and u-LFABP.},
  author={Stine Elkjaer Nielsen and Kasper Rossing and Georg Hess and Dietmar Zdunek and Berit Ruud Jensen and Henrik Parving and Peter Rossing},
  journal={Scandinavian journal of clinical and laboratory investigation},
  year={2012},
  volume={72 2},
  pages={137-42}
}
AIM Blockade of the renin-angiotensin-aldosterone system (RAAS) affects both the glomerulus and tubules. We aimed to investigate the effect of irbesartan on the tubular markers: urinary (u) neutrophil gelatinase associated protein (NGAL), Kidney injury molecule 1 (KIM1) and liver-fatty acid-binding protein (LFABP). METHODS A substudy of a double-masked, randomized, cross-over study including 52 patients with type 2 diabetes, hypertension and microalbuminuria. After 2 months washout of all… CONTINUE READING

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