The effect of PHA stimulation on lymphocyte sub-populations in whole-blood cultures.

@article{ODonovan1995TheEO,
  title={The effect of PHA stimulation on lymphocyte sub-populations in whole-blood cultures.},
  author={Michael Richard O'Donovan and Stephanie Johns and Phillip Wilcox},
  journal={Mutagenesis},
  year={1995},
  volume={10 4},
  pages={371-4}
}
Although lymphocytes in phytohaemagglutinin (PHA)-stimulated whole blood cultures are routinely used to assess genotoxin-induced chromosome damage, very little information is available on the effect of PHA on the various cell populations present, and there appear to be no data for the protocols used in routine genotoxicity assays. In this study, we used flow cytometric analysis to examine the size/complexity of the white blood cell (WBC) population and the expression of key antigenic markers by… CONTINUE READING

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