The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals.

@article{Koh2004TheEO,
  title={The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals.},
  author={Seong-Ho Koh and Younjoo Park and Chi Won Song and Jun Gyou Kim and Kisok Kim and Juhan Kim and Myung-Ho Kim and Seung Ro Lee and Dong Won Kim and H Yu and Dae-il Chang and Se Jin Hwang and Seung Hyun Kim},
  journal={The European journal of neuroscience},
  year={2004},
  volume={20 6},
  pages={1461-72}
}
Poly(ADP-ribose) polymerase (PARP) plays an important role in ischaemic cell death, and 3-aminobenzamide (3-AB), one of the PARP inhibitors, has a protective effect on ischaemic stroke. We investigated the neuroprotective mechanisms of 3-AB in ischaemic stroke. The occlusion of middle cerebral artery (MCA) was made in 170 Sprague-Dawley rats, and reperfusion was performed 2 h after the occlusion. Another 10 Sprague-Dawley rats were used for sham operation. 3-AB was administered to 85 rats 10… CONTINUE READING
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