The effect of Ndrg2 expression on astroglial activation.

  title={The effect of Ndrg2 expression on astroglial activation.},
  author={Toshiaki Takeichi and Mika Takarada-Iemata and Koji Hashida and Hirofumi Sudo and Tomohiko Okuda and Koichi Kokame and Taku Hatano and Masashi Takanashi and Sayaka Funabe and Nobutaka Hattori and Osamu Kitamura and Yasuko Kitao and Osamu Hori},
  journal={Neurochemistry international},
  volume={59 1},
N-myc downstream-regulated gene 2 (Ndrg2) is a differentiation- and stress-associated molecule predominantly expressed in astrocytes in the central nervous system (CNS). To study the expression and possible role of Ndrg2 in quiescent and activated astrocytes, mice were administrated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP), a Parkinson disease (PD)-related neurotoxin which causes both neurodegeneration and glial activation. Immunohistological analysis revealed that Ndrg2 was… CONTINUE READING