The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study.

@article{ArendtNielsen1995TheEO,
  title={The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study.},
  author={Lars Arendt-Nielsen and Steen Petersen-Felix and Matthias Konstantin Fischer and Peter Bak and Peter J Bjerring and Alex M. Zbinden},
  journal={Anesthesia and analgesia},
  year={1995},
  volume={81 1},
  pages={63-8}
}
Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor channel blocker known to inhibit "wind-up" and hence central hyperexcitability of dorsal horn neurons. We sought to assess the effect of ketamine on single and repeated nociceptive stimuli. A placebo-controlled, human (12 volunteers) experimental study was conducted in which several psychophysical (pain detection and tolerance thresholds, magnitude ratings) and electrophysiologic (withdrawal reflex) techniques were used 1) to… CONTINUE READING