• Chemistry, Medicine
  • Published in
    Advances in peritoneal…
    1998

The effect of N-acetylglucosamine as a substrate for in vitro synthesis of glycosaminoglycans by human peritoneal mesothelial cells and fibroblasts.

@article{Brborowicz1998TheEO,
  title={The effect of N-acetylglucosamine as a substrate for in vitro synthesis of glycosaminoglycans by human peritoneal mesothelial cells and fibroblasts.},
  author={Andrzej Bręborowicz and M Kuzlan-Pawlaczyk and Katarzyna Wieczorowska-Tobis and Justyna Wiśniewska and Paul Wing Ming Tam and I French and George Wu},
  journal={Advances in peritoneal dialysis. Conference on Peritoneal Dialysis},
  year={1998},
  volume={14},
  pages={
          31-5
        }
}
The effect of N-acetylglucosamine (NAG) on in vitro synthesis of glycosaminoglycans by human peritoneal mesothelial cells and fibroblasts was studied. In contrast to isosmotic concentrations of glucose, NAG increases the synthesis of hyaluronan by mesothelial cells and fibroblasts in a dose-dependent manner. This effect of NAG can be demonstrated in the presence of increased glucose levels in a medium, or in a medium mixed with effluent dialysate obtained from continuous ambulatory peritoneal… CONTINUE READING

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