The effect of Mycoplasma arthritidis infection on the kinetics of colloidal carbon clearance in mice.

  title={The effect of Mycoplasma arthritidis infection on the kinetics of colloidal carbon clearance in mice.},
  author={Evangelia Kaklamani and D. Karalis and Y Koumandaki and P. Kaklamanis and E K Katsouyanni and Revekka Tzanetea and C. Caroline Blackwell and L. Sparos and Donald Mackay Weir and Dimitrios Trichopoulos},
  journal={FEMS immunology and medical microbiology},
  volume={6 4},
The activity of phagocytes from A/J mice was estimated by the carbon clearance test following injection of Mycoplasma arthritidis. Phagocytic activity was significantly depressed 12 h post-infection (P = 0.001) and returned to normal values at 24 h. For animals examined 2 and 7 days post-infection, the overall phagocytic activity increased significantly (P < 10(-4). Phagocytic activity gradually decreased and returned to that of the control group by the end of the fourth week. The relative… 
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Does intrinsic immune defect against common microbial pathogens play an important role in arthritic manifestation
This review deals with infection connection and defective immune mechanism of rheumatoid manifestation for further better understanding of etiopathogenesis.
The phagocytosis of mycoplasmas.


The effect of Mycoplasma arthritidis infection on the phagocytic activity of macrophages in rats and mice.
The phagocytic activity of mononuclear phagocytes of A/J mice and Wistar rats was estimated by the carbon clearance test following injection of Mycoplasma arthritidis and there was not, however, an increase in the relative weight of liver and spleen as observed for the mice.
Interaction of Mycoplasma arthritidis and Other Mycoplasmas with Murine Peritoneal Macrophages
Neither mouse nor rat peritoneal macrophages were able to kill Mycoplasma arthritidis to any observable degree in the absence of specific hyperimmune rabbit antiserum. Although convalescent mouse and
Chronic Proliferative Arthritis of Mice Induced by Mycoplasma arthritidis I. Induction of Disease and Histopathological Characteristics
The clinical course and histopathological characteristics of the chronic phase of mouse arthritis induced by M. arthritidis closely resembled those of rheumatoid arthritis of man.
The immunosuppressive effect of mycoplasma infection. I. Effect on the humoral and cellular response.
It was concluded that immunosuppression might be the result of the effect of M. arthritidis on a particular population of cells.
Klebsiella pneumoniae glycoprotein RU-41740 enhances resistance of mice against Mycoplasma arthritidis-induced arthritis.
It is suggested that RU-41740 protects the mice by stimulating macrophages, and this immunostimulant might prove useful in the treatment of mycoplasma diseases, especially in the immunocompromised host.
Immunosuppressive properties of the Mycoplasma arthritidis T-cell mitogen in vivo: inhibition of proliferative responses to T-cell mitogens
It is hypothesize that MAM may play a role in M. arthritidis-mediated disease by both its inflammatory and immunosuppressive properties as well as major histocompatibility complex restrictions.
Induction of interleukin-6 in murine bone marrow-derived macrophages stimulated by the Mycoplasma arthritidis mitogen MAS.
It is demonstrated that MAS induces interleukin-6 (IL-6) in murine bone-marrow derived macrophage cultures using C3H/HeJ mice, which are known to be LPS-nonresponders, in all studies.
The kinetics of carbon clearance in rabbits stimulated by a tubercle bacillary lipid. A statistical model for carbon clearance studies.
The kinetics of the clearance of colloidal carbon from the blood of rabbits given an intravenous injection of 10 mg of a tubercle bacillary lipid were investigated and provide a statistical model for a “double exponential” assessment of stimulated carbon clearance rates.
Toxicity but not arthritogenicity of Mycoplasma arthritidis for mice associates with the haplotype expressed at the major histocompatibility complex
The use of inbred and congenic mouse strains established that toxicity and death induced by Mycoplasma arthritidis associates with the haplotype expressed at the murine major histocompatibility complex, whereas those bearing H-2b are much more resistant.