The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward

@article{Herberg1989TheEO,
  title={The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward},
  author={L. J. Herberg and I. C. Rose},
  journal={Psychopharmacology},
  year={1989},
  volume={99},
  pages={87-90}
}
MK-801 is a ligand at phencyclidine recognition sites associated with NMDA-coupled cation channels, where it acts as a potent noncompetitive antagonist of central glutamate/aspartate (NMDA-type) receptors. Low doses (10–100 μg/kg IP) produced a dose-related and prolonged (>1 h) enhancement of variable-interval self-stimulation responding. Higher doses (300 μg/kg) caused flaccid ataxia and disrupted responding. Ketamine HCl (3.0–100 mg/kg IP), a dissociative anaesthetic binding to the… CONTINUE READING

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