The effect of LSD-25 on light-reinforced behaviour in the rat

  title={The effect of LSD-25 on light-reinforced behaviour in the rat},
  author={Geoff Lowe and D. I. Williams},
Hallucinogenic drugs may produce changes in the neurophysiological response to sensory input, and it is suggested that corresponding behavioural changes may be monitored by an animal's reaction to response contingent visual stimulation. LSD-25 was shown to depress responding in rats for light onset and offset at dose levels which showed no depression of basic operant (non-reinforced) responding. This effect was observed under different post-injection intervals. In a parallel study using a… 
Haloperidol and light reinforcement in the rat
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  • Psychology, Biology
  • 2004
D Drugged animals responded significantly more for response contingent flickering light (RCF) and less for steady light (RCL) than saline injected animals, consistent with the possible arousal decreasing action of haloperidol and with the notion of an optimum level of arousal.
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Influence of cue‐conditioning on acquisition, maintenance and relapse of cocaine intravenous self‐administration
Analysis of the effects of a drug‐associated cue light on acquisition, maintenance and reinstatement of intravenous cocaine self‐administration shows that cocaine‐associated explicit cues do not directly interfere with the reinforcing effects of the drug.


Effects of Cyprenorphine Hydrochloride on Sensory Reinforcement in the Rat
This drug (in common with other hallucinogenic agents) may raise the arousal level of an animal that is relatively deprived visually, so that it needs very little further stimulation.
The effect of drugs on discrimination and sensory generalisation of auditory stimuli in cats
  • B. Key
  • Biology, Psychology
  • 2004
LS 25 (15 μg/kg) produced a significant decrease in the rate of extinction of a conditioned avoidance response and, although not modifying the degree to which the conditioned response was generalised to other, novel auditory stimuli, elicited a marked effect on the number of tones capable of evoking barrier crossing responses.
Studies in the effect of lysergic acid diethylamide (LSD-25): self- and object-size perception in schizophrenics and normal adults.
The study deals with the effect of LSD on size perception of one's own body and objects in space and that alterations in organismic state produced by LSD are reflected by changes in perception.
Effects of infantile handling on light-reinforced behaviour in the rat
Some Effects of a Hallucinogenic Compound (Cyprenorphine Hydrochloride; M 285) on the Light Reinforced Behaviour of Rats
CYPRENORPHINE hydrochloride (M 285)1 is a morphine antagonist with greater potency (about 35 times) parenterally and longer duration of action than nalorphine. It has been surveyed for
Response contingent illumination change as a reinforcer in the rat
The effect of drugs on arousal responses produced by electrical stimulation of the reticular formation of the brain.
  • P. Bradley, B. Key
  • Psychology, Biology
    Electroencephalography and clinical neurophysiology
  • 1958
Differential reinforcing effects of steady and flickering light on bar pressing in the rat
The present study, using a 15-rrtin pretest period, showed higher response rates for steady light than for flickering light, which cannot be explained in terms of the parameters of the reinforcing stimulus.
Light Reinforcement in the Rat: The Effects of Continuous and Discontinuous Periods of Apparatus Familiarization
The effects of continuous and discontinuous periods of apparatus familiarization on light reinforcement in rats were examined. A previous finding that the light reinforcement effect is greater with
Light Reinforcement following Pre-Adaptation in the Illuminated Test Apparatus
The failure to demonstrate a light reinforcement effect in Group CL, despite the fact that on Day 3 the light onset did constitute a change from the stimulus condition of the dark box, provides more impressive evidence for scanning theory.