The effect of L-Arginine on the brain tissue of stressed rats
@article{Ebadi2010TheEO, title={The effect of L-Arginine on the brain tissue of stressed rats}, author={B. Ebadi and Mehdi Mehdizadeh and Arezo Nahavandi and T Shariati and Hamdollah Delaviz}, journal={Basic and clinical neuroscience}, year={2010}, volume={1}, pages={33-36} }
Introduction: This study was conducted to determine the possible beneficial results of L-arginine on prefrontal cortex of rats which impressed by immobilization stress to define the synchronous impression of stress and nitric oxide (NO) on evolution of prefrontal cortex of rats after birth. Methods: Forty-eight one month, male Wistar rats were divided into two groups: stressed and non-stressed. L-Arginine (200 mg/kg) as a NO synthase (NOS) inducer and L-NAME (2O mg/kg) were injected…Â
One Citation
L-Arginine, Suatu Peluang Neuroproteksi terhadap Pasien Preeklampsia yang mendapat Problem Neurologis
- MedicineJurnal Neuroanestesi Indonesia
- 2019
Patients with preeclampsia shows an increase in cerebral perfussion pressure (CPP) in anterior, middle and posterior cerebral arteries, with accompanying changes in cerebral artery resistance indices.
References
SHOWING 1-10 OF 34 REFERENCES
Chronic Stress Induces the Expression of Inducible Nitric Oxide Synthase in Rat Brain Cortex
- BiologyJournal of neurochemistry
- 2000
Investigation of the role of endogenously released nitric oxide in stress and the possible induction of the inducible NO synthase (iNOS) isoform indicates that a sustained overproduction of NO via iNOS expression may be responsible for some of the neurodegenerative changes caused by stress and support a possible neuroprotective role for specific iNos inhibitors in this situation.
Psychological stress-induced enhancement of brain lipid peroxidation via nitric oxide systems and its modulation by anxiolytic and anxiogenic drugs in mice
- Biology, PsychologyBrain Research
- 1999
Lipid peroxidation during acute stress.
- MedicineDie Pharmazie
- 1996
The results of this study showed the increase of LPO in the heart, stomach and liver under stress conditions, which could be supposed that LPO may be involved in mechanisms of stress injury in different tissues.
Studies on lipid peroxidation in the rat brain
- Biology, ChemistryNeurochemical Research
- 2004
A simple and reliable procedure for assessing lipid peroxidation (L.P.) and testing the activity of antioxidant compounds and inhibiting agents is established, provided that the experimental conditions are carefully assessed.
Limb Reduction Defects after Prenatal Inhibition of Nitric Oxide Synthase in Rats
- MedicinePediatric Research
- 1995
The findings suggest that basal NO release is upregulated during fetal development concurrent with the processes that increase maternal NO release and that up-regulation of NO release occurs throughout the fetal systemic circulation and is not restricted to hindlimbs.
Perinatal Nitric Oxide Synthase Inhibition Retards Neonatal Growth by Inducing Hypertrophic Pyloric Stenosis in Rats
- MedicinePediatric Research
- 1995
It is concluded that NO, formed via the constitutive isoforms of NOS, is a critical determinant of fetal and neonatal growth and maturation and not aminoguanidine, the predominate inhibitor of inducible NOS.
Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats
- Biology, PsychologyFASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 1996
Findings provide evidence to support the idea that stress produces oxidants, and that the oxidative damage in stress could contribute to the degenerative diseases of aging, including brain dysfunction.
Increased in vitro lipid peroxidation of gerbil cerebral cortex as compared with rat
- BiologyNeuroscience Letters
- 1986
Neither L-NAME nor L-arginine changes extracellular glutamate elevation and anoxic depolarization during global ischemia and reperfusion in rat.
- BiologyNeuroreport
- 1999
The study suggests that NO is not an important mediator of glutamate release during ischemia and reperfusion, and instead suggests that L-NAME, L-arginine, and vehicle-treated animals should be considered as important mediators.
Nitric Oxide Donors Increase Blood Flow and Reduce Brain Damage in Focal Ischemia: Evidence That Nitric Oxide is Beneficial in the Early Stages of Cerebral Ischemia
- Medicine, BiologyJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- 1994
No donors increase CBF to the ischemic territory and reduce the tissue damage resulting from focal ischemia and the findings suggest that NO donors may represent a new therapeutic strategy for the management of acute stroke.