The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin--a double-blind, placebo-controlled, human experimental study.

@article{Andersen1996TheEO,
  title={The effect of Ketamine on stimulation of primary and secondary hyperalgesic areas induced by capsaicin--a double-blind, placebo-controlled, human experimental study.},
  author={Ole K{\ae}seler Andersen and Sven Felsby and L Nicolaisen and Peter J Bjerring and Troels Staehelin Jensen and Lars Arendt-Nielsen},
  journal={Pain},
  year={1996},
  volume={66 1},
  pages={51-62}
}
The non-competitive NMDA-antagonist, Ketamine, was infused (i.v.) in healthy volunteers to study the effect on central excitability with the presence of cutaneous hyperalgesia. Hyperalgesia was established experimentally on the dorsum of the foot by topical application of capsaicin (1%). Different thermal and mechanical conditioning stimuli were applied to the primary and secondary hyperalgesic areas to modulate the central nociceptive excitability monitored by the nociceptive reflex. When the… CONTINUE READING