The effect of Innovar versus droperidol or fentanyl on the duration of action of succinylcholine.

Abstract

The purpose of this paper is to investigate a phenomenon denied by Collins1 in 1976, but supported in later studies by Wehner 2 in 1979 and Lewis8 in 1982. The phenomenon is potentiation of the muscle relaxing action of succinylcholine by the neuroleptanesthesia agent Innovar,® as measured with a peripheral nerve stimulator. The two types of muscle relaxants used are non-depolarizing and depolarizing. Agents which belong in the non-depolarizing class include tubocurarine, pancuronium, and gallamine. 1.' These agents combine with the cholinergic receptor and prevent the action of acetylcholine (Ach)-that is, depolarization. In the model7 reviewed by Bradshaw, in 1980, the agent competes with Ach. In the receptor-ionophore model," the non-depolarizing agent enters the ionophore channel and prevents the action of Ach. It is not a competitive block in this model. A small dose of tubocurarine may be given approximately five minutes prior to the administration of Sch to prevent succinylcholine-induced fasciculations.' 6 Succinylcholine (Sch) is in the depolarizing class of muscle relaxants.' Its action is similar to

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Cite this paper

@article{Moore1986TheEO, title={The effect of Innovar versus droperidol or fentanyl on the duration of action of succinylcholine.}, author={Greg Moore and S A Ciresi and Shiminder Kallar}, journal={AANA journal}, year={1986}, volume={54 2}, pages={130-6} }