The effect of Helicobacter pylori eradication therapy on the development of gastroesophageal reflux disease.

Abstract

BACKGROUND It is uncertain whether the Helicobacter pylori eradication therapy makes a role in the progression of gastroesophageal reflux disease (GERD). METHODS A meta-analysis was undertaken to investigate the effect of H pylori eradication therapy on the development of GERD. RESULTS Overall, 16 cohort studies were included. The authors demonstrated that H pylori eradication had no significant effect on the occurrence of GERD in these cohort studies (odds ratio = 0.87, 95% confidence interval = 0.66-1.14, I = 32.4%, P = 0.103). CONCLUSIONS In general, H pylori eradication has no significant effect on the development of GERD in the long term. However, eradication therapy should be taken once there is H pylori infection, because H pylori infection is acknowledged to be a major cause of acute and chronic gastritis and peptic ulcer diseases and has been established as a definite etiologic factor for gastric cancer.

DOI: 10.1097/MAJ.0000000000000429

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@article{Tan2015TheEO, title={The effect of Helicobacter pylori eradication therapy on the development of gastroesophageal reflux disease.}, author={JiaCheng Tan and Ying Wang and Xiaomeng Sun and Wenxia Cui and Jianchao Ge and Lin Lin}, journal={The American journal of the medical sciences}, year={2015}, volume={349 4}, pages={364-71} }