The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells.

@article{MausnerFainberg2008TheEO,
  title={The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells.},
  author={Karin Mausner-Fainberg and Galia Luboshits and Adi Mor and Sophia Maysel-Auslender and Ardon Rubinstein and Gad Keren and Jacob George},
  journal={Atherosclerosis},
  year={2008},
  volume={197 2},
  pages={829-39}
}
Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are in widespread use due to their LDL reducing properties and concomitant improvement of clinical outcome in patients with and without preexisting atherosclerosis. Considerable evidence suggests that immune mediated mechanisms play a dominant role in the beneficial effects of statins. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) have a key role in the prevention of various inflammatory and autoimmune… CONTINUE READING

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