The effect of H2-antagonists on the absorption of bupropion in rats.

@article{AlKhamis1988TheEO,
  title={The effect of H2-antagonists on the absorption of bupropion in rats.},
  author={Khalil I. Al-Khamis and Juzar S. Kaka and Musbah O. M. Tanira},
  journal={Research communications in chemical pathology and pharmacology},
  year={1988},
  volume={59 2},
  pages={
          279-82
        }
}
Bupropion absorption was investigated by oral administration of bupropion alone or in combination with cimetidine or ranitidine to rats. Blood samples were collected before and at 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 3.0, 4.5 and 6 h after bupropion administration. The assay of bupropion in plasma was carried out by an HPLC method. Cimetidine or ranitidine did not significantly affect the plasma bupropion concentrations on concurrent administration. No significant differences were observed between… CONTINUE READING

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