The effect of GTP on the aluminum fluoride- and forskolin-activated adenylyl cyclase from human embryonic kidney 293 cells.

Abstract

GTP has been shown to inhibit AlF4(-)-stimulated, and to activate forskolin-stimulated adenylyl cyclase activity in the presence of Mg2+ in cell membranes from human embryonic kidney 293 cells. The maximal inhibitory response of AlF4(-)-stimulated adenylyl cyclase activity by GTP was not dependent on the concentration of Mg2+, but was so in the case of… (More)

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