The effect of GABA receptor ligands in experimental spina bifida occulta

@article{Briner2001TheEO,
  title={The effect of GABA receptor ligands in experimental spina bifida occulta},
  author={Wayne E. Briner},
  journal={BMC Pharmacology},
  year={2001},
  volume={1},
  pages={2 - 2}
}
BACKGROUND The pathophysiology behind spina bifida and other neural tube defects (NTDs) is unclear. Folic acid is one variable, but other factors remain. Studies suggest that substances active at the GABA receptor may produce NTDs. To test this hypothesis pregnant rats were exposed to either the GABA a agonist muscimol (1, 2 or 4 mg/kg), the GABA a antagonist bicuculline (.5, 1, or 2 mg/kg), the GABA b agonist baclofen (15, 30, 60 mg/kg), or the GABA b antagonist hydroxysaclofen (1, 3, or 5 mg… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Excessive Zinc Administration During Neural Tube Formation Effects Neuromuscular De- velopment of the Rat

T Wadkins, J Benz, W Briner
In Proceedings of the Fifth International Sympo- sia of Metal Ions in Biology and Medicine (Edited • 1998
View 1 Excerpt

GABAergic cells and signals in CNS development.

Perspectives on developmental neurobiology • 1998
View 2 Excerpts

Chiari malformation produced by GABA agonists muscimol and baclofen in rats

JD Ball, Briner W Arnold
FASEB • 1997

Muscimol and baclofen induced spina bifida in the rat

W Briner
Med Sci Res • 1996

Similar Papers

Loading similar papers…