The effect of GABA receptor ligands in experimental spina bifida occulta

  title={The effect of GABA receptor ligands in experimental spina bifida occulta},
  author={Wayne E. Briner},
  journal={BMC Pharmacology},
  pages={2 - 2}
BACKGROUND The pathophysiology behind spina bifida and other neural tube defects (NTDs) is unclear. Folic acid is one variable, but other factors remain. Studies suggest that substances active at the GABA receptor may produce NTDs. To test this hypothesis pregnant rats were exposed to either the GABA a agonist muscimol (1, 2 or 4 mg/kg), the GABA a antagonist bicuculline (.5, 1, or 2 mg/kg), the GABA b agonist baclofen (15, 30, 60 mg/kg), or the GABA b antagonist hydroxysaclofen (1, 3, or 5 mg… CONTINUE READING


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