The effect of DNA damage on the pattern of immune-detectable DNA methylation in mouse embryonic fibroblasts.

@article{elik2015TheEO,
  title={The effect of DNA damage on the pattern of immune-detectable DNA methylation in mouse embryonic fibroblasts.},
  author={Selcen Çelik and Yan Li and Christopher O'Neill},
  journal={Experimental cell research},
  year={2015},
  volume={339 1},
  pages={20-34}
}
The methylation of cytosine at CpG dinucleotides (5 meC) is an important epigenetic mechanism that governs genome stability and gene expression. Important ontological and pathological transitions are associated with marked global changes in detectable levels of methylation. We have previously found two pools of immune-detectable 5 meC exist within cells, a pool that can be detected after acid treatment of fixed cells to denature chromatin and another large but variable pool that requires a… CONTINUE READING
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