The effect of D-glucosamine on the adenine and uridine nucleotides of sarcoma 180 ascites tumor cells.

@article{Bekesi1969TheEO,
  title={The effect of D-glucosamine on the adenine and uridine nucleotides of sarcoma 180 ascites tumor cells.},
  author={Julius George Bekesi and Richard J. Winzler},
  journal={The Journal of biological chemistry},
  year={1969},
  volume={244 20},
  pages={
          5663-8
        }
}
  • J. BekesiR. Winzler
  • Published 25 October 1969
  • Biology, Chemistry
  • The Journal of biological chemistry
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The inhibition of thymidine kinase in glial tumor cells by an amino sugar, D-glucosamine.

Thymidine kinase activity in rat C6 glioma cells is inhibited by 50 to 70% after 4 hr incubation with 20 mM D-glucosamine, and the kinetics of recovery of amino acid incorporation from inhibition was rapid, but the activity was depressed for at least 6 hr after drug washout.

Inhibitory effects of D-glucosamine on the growth of Walker 256 carcinosarcoma and on protein, RNA, and DNA synthesis.

The resistance of rats and mice successfully treated with glucosamine to a second syngeneic tumor graft suggests that glucosamines treatment may interfere with the tumor in such a way as to permit the host to respond successfully to the antigenic makeup of the tumor.

Nucleotide contents of ascites hepatoma cells and their changes induced by D-galactosamine.

The extremely low UDP-glucose levels in both hepatoma cell lines may explain the virtual absence of glycogen and the relative ratios of adenosine phosphates determined by direct enzymatic analysis are significantly higher than those obtained by chromatographic separation of the nucleotides after labeling with adenosines-8- 14 C.

Effects of D-glucosamine, D-mannosamine, and 2-deoxy-D-glucose on the ultrastructure of ascites tumor cells in vitro.

Ehrlich ascites carcinoma and Sarcoma 180 ascites tumor cells were treated in vitro with amino sugars, and the resulting changes were studied by light and electron microscopy. Addition of…

A biochemical investigation into the inhibitory effects of glucosamine and N-acetylclucosamine on the aggregation in vitro of embryonic chick muscle cells.

The metabolic effects of these hexosamines on chick muscle cells in vitro are mainly attributed to a central alteration of the adenine nucleotide balance although certain other documented effects of glucosamine are considered to be involved.

Uridine triphosphate deficiency, growth inhibition, and death in ascites hepatoma cells induced by a combination of pyrimidine biosynthesis inhibition with uridylate trapping.

Noncompensated nucleotide trapping may be useful for an induction of selective nucleotide deficiencies in tumor cells and can be extended to other inhibitors of nucleotide synthesis combined with various nucleotide-trapping sugar analogs.
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5 References

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    R: WILLIAMSON’ (Editors), Cork1 of energy metabo: lism, Academic Press, New York, 1965, p

    • 157. 33. COE, E. L., Biochim. Biophys. Acta, 118, 495 (1966). 34. CREASER, E. H., AND SCHOLEFIELD, P. G., Cancer Res., 20, 257
    • 1960

    SORKIN, A., AND RHODES

    • J. M., Exp. Cell Res., 10,
    • 1956

    Winzler Sarcoma 180 Ascites Tumor Cells The Effect of d-Glucosamine on the Adenine and Uridine Nucleotides of

    • 1969

    Pk. bat. Acad. k'ci

    • 1964