The effect of D-glucosamine on the adenine and uridine nucleotides of sarcoma 180 ascites tumor cells.

  title={The effect of D-glucosamine on the adenine and uridine nucleotides of sarcoma 180 ascites tumor cells.},
  author={Julius George Bekesi and Richard J. Winzler},
  journal={The Journal of biological chemistry},
  volume={244 20},
  • J. Bekesi, R. Winzler
  • Published 25 October 1969
  • Biology, Medicine
  • The Journal of biological chemistry
Abstract The effect of d-glucosamine on the metabolism of adenine and uridine nucleotides in Sarcoma 180 ascites tumor cells was investigated as part of an effort to determine the biochemical basis for the cytotoxic effects of glucosamine on tumor cells. Incubation of ascites tumor cells with exogenous glucosamine resulted in a 4-fold increase in the pool size of UDP-N-acetylhexosamine. A large fraction of 14C-labeled uridine was accumulated as radioactive UDP-N-acetylhexosamine when the cells… Expand
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